Smad5 Induces Ventral Fates inXenopusEmbryo
نویسندگان
چکیده
منابع مشابه
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling.
We have previously shown that the maternal effect dorsalization of zebrafish embryos from sbn(dtc24) heterozygous mothers is caused by a dominant negative mutation in Smad5, a transducer of ventralizing signaling by the bone morphogenetic proteins Bmp2b and Bmp7. Since sbn(dtc24) mutant Smad5 protein not only blocks wild-type Smad5, but also other family members like Smad1, it remained open to ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1997
ISSN: 0012-1606
DOI: 10.1006/dbio.1997.8548